The collection consists primarily of correspondence between Dr. Robert Donnell Bone and his wife, Griselda Minerva Burk Bone, documenting family life and Dr. Bone's Civil War service as Assistant Surgeon of the 12th Texas Volunteer Infantry. Also included are letters from family and friends, Douglass, Texas, post office reports, two poems attributed to Dr. Bone, typescript copies of most documents, and a small group of nineteenth-century newspapers.

This is a small collection and consists primarily of photographs and newspaper clippings about the family of Charles H. Tindall. The collection also includes a song book and Dr. Tindall's prescription book.

The collection contains papers, letters and medical diplomas belonging to Clarence P. Harris and his family.

There are three ledgers 1914-1917, 1918-1920, and 1921-1927 from Dr. W. A. Ramsey's office.

Original handwritten letters from prominent early Nacogdoches and Marshall citizen, James Harper Starr, to James and Susan Thorn concerning business and personal events.

Doctor's account book listing patients' names or relation to head of household and sometimes type of treatment or prescription with costs. Patients were from Nacogdoches and San Augustine counties.